Avicenna Journal of Clinical Microbiology and Infection

8/1/2018

Review Article

Inside Helicobacter pylori: A Serious Threat to Humans

Abdul Rehman

DOI: 10.5812/ajcmi.60463

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Helicobacter pylori is a close relative of Campylobacter species, with the ability to colonize the human gastrointestinal tract. This gastric pathogen is a flagellated, Gram-negative bacterium. Chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, duodenal ulcer, and gastric ulcer are the outcomes of persistent infection with this pathogen. Recent studies have shown a direct relationship between H. pylori and development of gastric adenocarcinoma. A 7- to 14-day course of broad-spectrum antibiotics is required for the elimination of H. pylori. Treatment failure due to chromosomally encoded antibiotic resistance is increasing rapidly, which underlines the importance of new regimens against this pathogen. The vast diversity of natural compounds in living microorganisms such as algae, as well as various dietary components in herbs and foods, provides a new opportunity for the establishment of therapeutic compounds. The majority of intra- and extracellular metabolites in algae have potent inhibitory effects on H. pylori, leading to the development of novel therapeutic agents for gastric ulcer. Application of bioinformatics-based tools has encouraged the scientific community to find novel targets and have led to the development of in silico drugs against the pathogenic elements of H. pylori. Further research on metabolite-based therapeutic agents with the aid of modern tools can be a milestone in the management of the emerging risk of gastric ulcer.

27/11/2017

Research Article

Antibacterial Activity of Azadirachta indica Leaf Extracts Against Some Pathogenic Standards and Clinical Bacterial Isolates

Leila Maleki, Tahereh Sadeghian-Rizi, Mostafa Ghannadian, Mohammad Hossein Sanati, Shahin Shafizadegan, Hojjat Sadeghi-Aliabadi

DOI: 10.5812/ajcmi.12987

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Results: The results revealed that methanol extract has the strongest growth inhibitory effect on both standard and clinical isolated strains of P. aeroginosa. Ethyl acetate and ethanol extracts, showing a growth inhibitory effect on both standard and hospital isolated strains of S. aureus. In the case of E. faecalis, ethanol and methanol extracts showed the highest growth inhibitory effect against standard and clinical strains, respectively. According to the MIC index results, the methanol extract has a bactericidal activity against both standard and nosocomial strains of S. aureus and P. aeroginosa and bacteriostatic activity against nosocomial strain of E. faecalis. Ethanol extract showed bactericidal activity against both standard and nosocomial strains of E. faecalis and P. aeroginosa and bacteriostatic activity against nosocomial strain of S. aureus. Ethyl acetate extract had shown bactericidal activity against standard strains of S. aureus and P. aeroginosa and bacteriostatic against nosocomial strain of S. aureus and standard strain of E. faecalis.

10/2/2018

Research Article

Detection of Toxic Shock Syndrome Toxin (tsst) Gene Among Staphylococcus aureus Isolated from Patients and Healthy Carriers

Reza Hakimi Alni, Abdolmajid Mohammadzadeh, Pezhman Mahmoodi, Mohammad Yousef Alikhani

DOI: 10.5812/ajcmi.14249

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25/2/2018

Research Article

The Prevalence of Panton-Valentine Lukocidin Gene in Staphylococcus aureus Species Isolated From Nosocomial Infections in Isfahan, Iran

Fahimeh Nourbakhsh, Samaneh Borooni, Elaheh Tajbakhsh

DOI: 10.5812/ajcmi.60088

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17/2/2018

Research Article

Antibiofilm Activity of Dracocephalum polychaetum Extract on Methicillin-Resistant Staphylococcus aureus

Mohammad Mehdi Yaghoobi, Mouj Khaleghi, Hajar Rezanejad, Paria Parsia

DOI: 10.5812/ajcmi.61772

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10/2/2018

Research Article

Improve ICG Based Photodynamic Properties Through Conjugation of ICG Into Nano-Graphene Oxide Against Enterococcus faecalis

Tayebeh Akbari, Maryam Pourhajibagher, Nasim Chiniforush, Sima Shahabi, Farzaneh Hosseini, Abbas Bahador

DOI: 10.5812/ajcmi.64624

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10/1/2018

Case Report

Erythema Induratum of Bazin: A Rare Presentation of Tuberculosis

Seyyed Hamid Hashemi, Mahmoud Farshchian, Hamidreza Ghasemi Basir, Maria Shirvani

DOI: 10.5812/ajcmi.64161

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Avicenna Journal of Clinical Microbiology and Infection

Published by: Kowsar

Avicenna Journal of Clinical Microbiology and Infection: Feb 2018, 5 (1), 7 articles.