Avicenna Journal of Clinical Microbiology and Infection

Published by: Kowsar

Antibiofilm Activity of Dracocephalum polychaetum Extract on Methicillin-Resistant Staphylococcus aureus

Mohammad Mehdi Yaghoobi 1 , * , Mouj Khaleghi 2 , Hajar Rezanejad 1 and Paria Parsia 2
Authors Information
1 Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, IR Iran
2 Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, IR Iran
Article information
  • Avicenna Journal of Clinical Microbiology and Infection: February 2018, 5 (1); e61772
  • Published Online: February 17, 2018
  • Article Type: Research Article
  • Received: September 15, 2017
  • Revised: January 8, 2018
  • Accepted: January 14, 2018
  • DOI: 10.5812/ajcmi.61772

To Cite: Yaghoobi M M, Khaleghi M, Rezanejad H, Parsia P. Antibiofilm Activity of Dracocephalum polychaetum Extract on Methicillin-Resistant Staphylococcus aureus, Avicenna J Clin Microb Infec. 2018 ;5(1):e61772. doi: 10.5812/ajcmi.61772.

Copyright © 2018, Avicenna Journal of Clinical Microbiology and Infection. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Purrello SM, Garau J, Giamarellos E, Mazzei T, Pea F, Soriano A, et al. Methicillin-resistant Staphylococcus aureus infections: A review of the currently available treatment options. J Glob Antimicrob Resist. 2016;7:178-86. doi: 10.1016/j.jgar.2016.07.010. [PubMed: 27889013].
  • 2. Laverty G, Gorman SP, Gilmore BF. Biomolecular mechanisms of staphylococcal biofilm formation. Future Microbiol. 2013;8(4):509-24. doi: 10.2217/fmb.13.7. [PubMed: 23534362].
  • 3. Le KY, Dastgheyb S, Ho TV, Otto M. Molecular determinants of staphylococcal biofilm dispersal and structuring. Front Cell Infect Microbiol. 2014;4:167. doi: 10.3389/fcimb.2014.00167. [PubMed: 25505739].
  • 4. Atshan SS, Shamsudin MN, Karunanidhi A, van Belkum A, Lung LT, Sekawi Z, et al. Quantitative PCR analysis of genes expressed during biofilm development of methicillin resistant Staphylococcus aureus (MRSA). Infect Genet Evol. 2013;18:106-12. doi: 10.1016/j.meegid.2013.05.002. [PubMed: 23669446].
  • 5. Nourbakhsh F, Namvar AE. Detection of genes involved in biofilm formation in Staphylococcus aureus isolates. GMS Hyg Infect Control. 2016;11:Doc07. doi: 10.3205/dgkh000267. [PubMed: 27303652].
  • 6. Lee JH, Park JH, Cho HS, Joo SW, Cho MH, Lee J. Anti-biofilm activities of quercetin and tannic acid against Staphylococcus aureus. Biofouling. 2013;29(5):491-9. doi: 10.1080/08927014.2013.788692. [PubMed: 23668380].
  • 7. CLSI . Performance Standards for Antimicrobial Susceptibility Testing;Twenty-Third Informational Supplement. Wayne, PA: Clinical and Laboratory Standards Institute; 2013.
  • 8. Ruijter JM, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, van den Hoff MJ, et al. Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res. 2009;37(6). e45. doi: 10.1093/nar/gkp045. [PubMed: 19237396].
  • 9. Taylor PW. Alternative natural sources for a new generation of antibacterial agents. Int J Antimicrob Agents. 2013;42(3):195-201. doi: 10.1016/j.ijantimicag.2013.05.004. [PubMed: 23796893].
  • 10. Lee SB, Cha KH, Kim SN, Altantsetseg S, Shatar S, Sarangerel O, et al. The antimicrobial activity of essential oil from Dracocephalum foetidum against pathogenic microorganisms. J Microbiol. 2007;45(1):53-7. [PubMed: 17342056].
  • 11. Kamali M, Khosroyar S, Mohammadi A. Antibacterial activity of various extracts from Dracocephalum kotschyi against food pathogenic microorganisms. Int J Pharm Tech Res. 2015;8(2):158-63.
  • 12. Asghari G, Nasr Esfahani B, Paydar P. Evaluating the effect of Dracocephalum kotschyi methanol extract on Mycobacterium tuberculosis. Res J Pharmacogn. 2015;2(3):31-6.
  • 13. Sonboli A, Gholipour A, Yousefzadi M. Antibacterial activity of the essential oil and main components of two Dracocephalum species from Iran. Nat Prod Res. 2012;26(22):2121-5. doi: 10.1080/14786419.2011.625501. [PubMed: 22007732].
  • 14. Mehrabani M, Roholahi S, Foruomadi A. Phytochemical studies of Dracocephalum polychaetum Bornm. J Med Plant. 2005;4(16):36-42.
  • 15. Usman Amin M, Khurram M, Khan TA, Faidah HS, Ullah Shah Z, Ur Rahman S, et al. Effects of Luteolin and Quercetin in Combination with Some Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus. Int J Mol Sci. 2016;17(11). doi: 10.3390/ijms17111947. [PubMed: 27879665].
  • 16. El-Haci IA, Bekhechi C, Atik-Bekkara F, Mazari W, Gherib M, Bighelli A, et al. Antimicrobial activity of Ammodaucus leucotrichus fruit oil from Algerian Sahara. Nat Prod Commun. 2014;9(5):711-2. [PubMed: 25026729].
  • 17. Liu M, Wu X, Li J, Liu L, Zhang R, Shao D. The specific anti-biofilm effect of gallic acid on Staphylococcus aureus by regulating the expression of the ica operon. Food Control. 2017;73:613-8.
  • 18. Khoramian B, Jabalameli F, Niasari-Naslaji A, Taherikalani M, Emaneini M. Comparison of virulence factors and biofilm formation among Staphylococcus aureus strains isolated from human and bovine infections. Microb Pathog. 2015;88:73-7. doi: 10.1016/j.micpath.2015.08.007. [PubMed: 26279194].

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Search Relations:


  • Mohammad Mehdi Yaghoobi: [PubMed] [Scholar]
  • Mouj Khaleghi: [PubMed] [Scholar]
  • Hajar Rezanejad: [PubMed] [Scholar]
  • Paria Parsia: [PubMed] [Scholar]
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