Avicenna Journal of Clinical Microbiology and Infection

Published by: Kowsar

Emergence of blaCTX-M-15 Gene and Its Transferability in Enterobacter spp. Isolated From the Hospitals of Tehran, Iran

Authors Information
1 Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
2 Department of Microbiology, Iranian Reference Health Laboratory, Deputy of Health, Ministry of Health and Medical Education, Tehran, IR Iran
Article Notes and Dates
Avicenna Journal of Clinical Microbiology and Infection: August 2015, 2 (3); e29691.Published Online: August 23, 2015
Article Type: Research Article; Received : May 11, 2015; Accepted : June 30, 2015
DOI: http://dx.doi.org/10.17795/ajcmi-29691

To Cite : Salimian Rizi K, Najar Peerayeh S, Bakhshi B, Rahbar M. Emergence of blaCTX-M-15 Gene and Its Transferability in Enterobacter spp. Isolated From the Hospitals of Tehran, Iran, Avicenna J Clin Microb Infec. 2015 ;2(3):e29691. doi: 10.17795/ajcmi-29691.

Copyright: Copyright © 0, Avicenna Journal of Clinical Microbiology and Infection. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Mezzatesta ML, Gona F, Stefani S. Enterobacter cloacae complex: clinical impact and emerging antibiotic resistance. Future Microbiol. 2012; 7(7): 887-902[DOI][PubMed]
  • 2. Sanders WEJ, Sanders CC. Enterobacter spp.: pathogens poised to flourish at the turn of the century. Clin Microbiol Rev. 1997; 10(2): 220-41[PubMed]
  • 3. Levison ME, Mailapur YV, Pradhan SK, Jacoby GA, Adams P, Emery CL, et al. Regional occurrence of plasmid-mediated SHV-7, an extended-spectrum beta-lactamase, in Enterobacter cloacae in Philadelphia Teaching Hospitals. Clin Infect Dis. 2002; 35(12): 1551-4[DOI][PubMed]
  • 4. Maynard C, Bekal S, Sanschagrin F, Levesque RC, Brousseau R, Masson L, et al. Heterogeneity among virulence and antimicrobial resistance gene profiles of extraintestinal Escherichia coli isolates of animal and human origin. J Clin Microbiol. 2004; 42(12): 5444-52[DOI][PubMed]
  • 5. Livermore DM, Canton R, Gniadkowski M, Nordmann P, Rossolini GM, Arlet G, et al. CTX-M: changing the face of ESBLs in Europe. J Antimicrob Chemother. 2007; 59(2): 165-74[DOI][PubMed]
  • 6. Boyd DA, Tyler S, Christianson S, McGeer A, Muller MP, Willey BM, et al. Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada. Antimicrob Agents Chemother. 2004; 48(10): 3758-64[DOI][PubMed]
  • 7. Coque TM, Novais A, Carattoli A, Poirel L, Pitout J, Peixe L, et al. Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15. Emerg Infect Dis. 2008; 14(2): 195-200[DOI][PubMed]
  • 8. Roopa TJ, Sudha SS. Antimicrobial susceptibility of extended spectrum beta –lactamase (ESBL) producing uropathogens isolated from ICU patients. Int J Biological Technology. 2010; 1: 23-31
  • 9. Szabo D, Bonomo RA, Silveira F, Pasculle AW, Baxter C, Linden PK, et al. SHV-type extended-spectrum beta-lactamase production is associated with Reduced cefepime susceptibility in Enterobacter cloacae. J Clin Microbiol. 2005; 43(10): 5058-64[DOI][PubMed]
  • 10. Aibinu IE, Ohaegbulam VC, Adenipekun EA, Ogunsola FT, Odugbemi TO, Mee BJ. Extended-spectrum beta-lactamase enzymes in clinical isolates of Enterobacter species from Lagos, Nigeria. J Clin Microbiol. 2003; 41(5): 2197-200[PubMed]
  • 11. Performance standards for antimicrobial susceptibility testing, 20th information supplement (M100-S20). 2012;
  • 12. Mendonca N, Louro D, Castro AP, Diogo J, Canica M. CTX-M-15, OXA-30 and TEM-1-producing Escherichia coli in two Portuguese regions. J Antimicrob Chemother. 2006; 57(5): 1014-6[DOI][PubMed]
  • 13. Harajly M, Khairallah MT, Corkill JE, Araj GF, Matar GM. Frequency of conjugative transfer of plasmid-encoded ISEcp1 - blaCTX-M-15 and aac(6')-lb-cr genes in Enterobacteriaceae at a tertiary care center in Lebanon - role of transferases. Ann Clin Microbiol Antimicrob. 2010; 9: 19[DOI][PubMed]
  • 14. Hausner M, Wuertz S. High rates of conjugation in bacterial biofilms as determined by quantitative in situ analysis. Appl Environ Microbiol. 1999; 65(8): 3710-3[PubMed]
  • 15. Phornphisutthimas S, Thamchaipenet A, Panijpan B. Conjugation in Escherichia coli: A laboratory exercise. Biochem Mol Biol Educ. 2007; 35(6): 440-5[DOI][PubMed]
  • 16. Iabadene H, Messai Y, Ammari H, Ramdani-Bouguessa N, Lounes S, Bakour R, et al. Dissemination of ESBL and Qnr determinants in Enterobacter cloacae in Algeria. J Antimicrob Chemother. 2008; 62(1): 133-6[DOI][PubMed]
  • 17. Mirsalehian A, Akbari NF, Peymani A, Kazemi B, Jabal A, Mirafshar SM. Prevalence of extended spectrum beta-lactamase-producing Enterobacteriaceae by phenotypic and genotypic methods in intensive care units in Tehran, Iran. Daru. 2008; 16(3): 169-73
  • 18. Kasap M, Fashae K, Torol S, Kolayli F, Budak F, Vahaboglu H. Characterization of ESBL (SHV-12) producing clinical isolate of Enterobacter aerogenes from a tertiary care hospital in Nigeria. Ann Clin Microbiol Antimicrob. 2010; 9: 1[DOI][PubMed]
  • 19. Morand PC, Billoet A, Rottman M, Sivadon-Tardy V, Eyrolle L, Jeanne L, et al. Specific distribution within the Enterobacter cloacae complex of strains isolated from infected orthopedic implants. J Clin Microbiol. 2009; 47(8): 2489-95[DOI][PubMed]
  • 20. Huang ZM, Shan H, Mi ZH, Yang HY, Wu L, Chu QJ, et al. [Analysis on 168 rRNA methylase genes and aminoglycoside modifying enzymes genes in Enterobacter cloacae in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2008; 29(4): 369-73[PubMed]
  • 21. Jabeen K, Zafar A, Hasan R. Frequency and sensitivity pattern of Extended Spectrum beta Lactamase producing isolates in a tertiary care hospital laboratory of Pakistan. J Pak Med Assoc. 2005; 55(10): 436-9[PubMed]
  • 22. Amin H, Zafar A, Ejaz H, Jameel NU. Phenotypic characterization of ESBL producing Enterobacter cloacae among children. Pak J Med Sci. 2013; 29(1): 144-7[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Cited By:

Search Relations:


  • Kobra Salimian Rizi: [PubMed] [Scholar]
  • Shahin Najar Peerayeh: [PubMed] [Scholar]
  • Bita Bakhshi: [PubMed] [Scholar]
  • Mohammad Rahbar: [PubMed] [Scholar]
  • Related Article in PubMed
  • Related Article in Google Scholar

Create Citiaion Alert via Google Reader